New York, New York - July 30, 2012 - Investorideas.com, an investor research portal specializing in sector research including biotech and pharma stocks, issues CFA commentary by Patrick J. Murphy of Murphy Analytics LLC on Sunshine Biopharma Inc. (OTCBB: SBFM) and its lead anti-cancer compound, Adva-27a.

 

Select Stock Trading Data

Recent Stock Price: $0.34

Shares Outstanding: 48.7 million

Float  13.9 million

Recent Market Cap: $16.8 million

52 Week Range:  $0.12 - $1.45

Exchange: OTCBB

Ticker: SBFM

URL:  http://www.sunshinebiopharma.com

Data sourced from Yahoo! Finance; otcbb.com; Company filings

Sunshine Bipharma, Inc. (SBFM) is focused on the research, development and commercialization of drugs for the treatment of various forms of cancer. SBFM reports that the preclinical studies for the Company's lead compound, Adva-27a, a multi-purpose anti-tumor compound, were successfully completed in late 2011. SBFM is now continuing the clinical development of Adva-27a by conducting the next sequence of steps comprised of GMP manufacturing, IND-enabling studies, regulatory filing and Phase I clinical trials. SBFM plans to conduct Phase I clinical trials for Adva-27a at the Jewish General Hospital, Montreal, Canada, one of McGill University's Hospital Centers.

The planned indication will be multidrug resistant breast cancer as SBFM reports that Adva-27a has shown remarkably strong cytotoxic activity against this type of cancer. In addition, on June 26, 2012, SBFM announced the completion of another cytotoxicity study in which Adva-27a was found to be significantly more effective at killing multidrug resistant small-cell lung cancer (SCLC) cells than etoposide, a drug commonly used currently for treating SCLC.

SBFM has licensed its technology on an exclusive basis from Advanomics Corporation and is planning to initiate its own research and development program as soon as practicable

An article in nature biotechnology summarizes the challenge multidrug resistance creates for developing effective treatments:

"Multidrug resistance, the principal mechanism by which many cancers develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapy. It affects patients with a variety of blood cancers and solid tumors, including breast, ovarian, lung, and lower gastrointestinal tract cancers. Tumors usually consist of mixed populations of malignant cells, some of which are drug-sensitive while others are drug-resistant. Chemotherapy kills drug-sensitive cells, but leaves behind a higher proportion of drug-resistant cells. As the tumor begins to grow again, chemotherapy may fail because the remaining tumor cells are now resistant."

As explained in an article published by the National Institutes of Health (NIH), this cellular response to toxins in the environment is critical for our survival and has evolved over time:

"Toxins in the environment are a major threat to many living organisms. Once internalized, toxic compounds must be removed for the organisms to survive. Therefore, humans have developed, inherited and perfected ways to reduce the effect of xenobiotics. At the cellular level, the cell membrane acts as a physical barrier to prevent compounds from entering the cell. However, because some compounds can diffuse through the cell membrane, alternative protective methods have evolved. One of the most important defense mechanisms is to pump xenobiotics out of the cells. Thus, drug transporters are commonly found in the cell membranes of many organisms, from bacteria to mammals, and are responsible for cell protection. However, the existence of these drug transporters often hinders the use of compounds used to treat diseases because they are substrates of these efflux pumps either by affecting the pharmacokinetics of drugs in the body or by limiting accumulation in target cells such as cancer cells."

SBFM reports that Adva-27a can overcome two of these xenobiotic pumps - multidrug resistant transporter proteins MDR1 and MRP1, which facilitate multidrug resistance, and as the NIH article notes, MDR1 in particular has become the most studied gene in the field of multidrug resistance.

As reference for the potential market opportunity for Adva-27a for treatment of small-cell lung cancer, the American Cancer Society estimates there will be 226,160 new cases of lung and bronchus cancer in the U.S. in 2012, with an estimated 160,340 deaths. The National Cancer Institute (NCI) estimates that small-cell lung cancer (SCLC) accounts for approximately 15% of bronchogenic carcinomas. While etoposide, now available as a generic, is used in combination with other medications to treat SCLC, the NCI addresses the challenge and urgency of developing a more effective treatment for SCLC, noting that:

"Regardless of stage, the current prognosis for patients with SCLC is unsatisfactory despite improvements in diagnosis and therapy made during the past 25 years. Without treatment, SCLC has the most aggressive clinical course of any type of pulmonary tumor, with median survival from diagnosis of only 2 to 4 months."

"For most patients with small cell lung cancer, current treatments do not cure the cancer. If lung cancer is found, patients should think about taking part in one of the many clinical trials being done to improve treatment. Clinical trials are taking place in most parts of the country for patients with all stages of small cell lung cancer."

In a recent interview, SBFM CFO Camile Sebaaly noted that the Company expects the first clinical trial of Adva-27a will be done on breast cancer volunteers at Jewish General Hospital. As the Company continues to do the work and raise the capital necessary to bring its drug to market, Mr. Sebaaly stated that the Company expects that if FDA approval is obtained, SBFM may have a similar sales profile to other important cancer drugs that have reached $1 billion in sales within 2 years of FDA approval.

Patrick Murphy Disclaimer:

Readers are advised that the above article is solely for information purposes and should not to be construed as an offer to sell or the solicitation of an offer to buy any security. The views expressed herein are based upon the author's analysis of the issuer's public disclosures, and assumes both their accuracy and completeness. The opinions and statements included herein are based on sources (including the companies discussed and public sources) believed to be reliable and in good faith, but no representation or warranty, express or implied, is made as to their accuracy, completeness or correctness. The author has not independently verified the information contained herein. This information is not intended to be used as the sole basis of any investment decisions, nor should it be construed as advice designed to meet the investment needs of any particular investor. You should review a complete information package on all companies, which should include, but not be limited to, the Company's annual report, quarterly reports, press releases and all regulatory filings. The foregoing discussion contains statements which are based on current expectations, estimates and projections, and differences from such expectations, estimates and projections can be expected. The author, Patrick Murphy, was compensated $510 by InvestorIdeas.com for writing this article. Murphy does not own shares of any of the companies mentioned in this article. Mr. Murphy's research firm, Murphy Analytics, may be engaged for the provision of a research report on the Company in the future.

About Sunshine Biopharma Inc. (OTCBB: SBFM):

Sunshine Biopharma is a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer. The Company's lead compound, Adva-27a targets aggressive forms of cancer.

www.sunshinebiopharma.com

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