Inovio Pharmaceuticals Enters Into Strategic Cancer Vaccine Collaboration and License Agreement With MedImmune

Agreement Includes Clinical-Stage INO-3112 HPV Cancer Vaccine and Preclinical Collaboration to Develop Additional Cancer Vaccine Candidates

Inovio Schedules Conference Call for 8:30am ET Today; Go to inovio.com and Click on "Webcast" Tab

PLYMOUTH MEETING, Pa., Aug. 10, 2015  -- Inovio Pharmaceuticals (INO) today announced that it has entered into a license agreement and collaboration with MedImmune, the global biologics research and development arm of AstraZeneca.

Under the agreement, MedImmune will acquire exclusive rights to Inovio's INO-3112 immunotherapy, which targets cancers caused by human papillomavirus (HPV) types 16 and 18. INO-3112, which is in phase I/II clinical trials for cervical and head and neck cancers, works by generating killer T-cell responses that are able to destroy HPV 16- and 18-driven tumors. These HPV types are responsible for more than 70 percent of cervical pre-cancers and cancers.

Aquinox Pharmaceuticals Announces Positive Results From Secondary Endpoints From Phase 2 LEADERSHIP Trial in BPS/IC and Reports Second Quarter 2015 Financial Results

VANCOUVER, British Columbia, Aug. 6, 2015  -- Aquinox Pharmaceuticals, Inc. ("Aquinox") (AQXP), a clinical-stage pharmaceutical company discovering and developing targeted therapeutics in disease areas of inflammation and immuno-oncology, today announced results from secondary endpoints from its Phase 2 LEADERSHIP trial with AQX-1125 in patients with bladder pain syndrome/interstitial cystitis (BPS/IC). Aquinox also provided a general business update and reported financial results for the second quarter ending June 30, 2015.

"Consistently positive results from multiple secondary endpoints have strengthened our confidence in further development of AQX-1125 for BPS/IC," said Mr. David Main, President and CEO of Aquinox. "The encouraging effect of AQX-1125 observed on the primary endpoint of reduction in pain together with several statistically significant secondary endpoints, underscore the potential of AQX-1125 as a once daily, oral therapy for this debilitating disease."

Oragenics Reports Positive In Vivo Antibiotic Efficacy Data in Critical Animal Study

Lead Lantibiotic Clinical Candidate Selected from MU1140 Analog Pipeline

TAMPA, Fla. & GERMANTOWN, Md.--- Oragenics, Inc. (NYSE MKT: OGEN) and Intrexon Corporation (XON), a leader in synthetic biology, announced today positive data on multiple compounds from Oragenics’ Mutacin 1140 (“MU1140”) lantibiotic platform in a critical animal model study, as well as the selection of a lead clinical candidate. The compounds were subjected to a standardized “proof of concept” animal model evaluating efficacy for reducing clinically relevant C. difficile infection(s) and increased survival relative to vancomycin positive control.

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Lantibiotics are a class of antibiotics with a novel mechanism of action active against several multi-drug resistant infectious agents. Through its Exclusive Channel Collaboration (“ECC”), Oragenics has utilized Intrexon’s proprietary bio-engineering capabilities to develop its MU1140 analog pipeline which could provide an important new tool in the fight against global bacterial antibiotic resistance.

Cryoport's Portfolio of Temperature-Managed Clinical Programs Expands to 45 Trials

LAKE FOREST, Calif., July 27, 2015  -- Cryoport, Inc. (CYRX) ("Cryoport" or the "Company"), the leading provider of advanced cryogenic logistics solutions for the life sciences industry, with markets including immunotherapies, stem cells, cell lines, clinical research organizations, vaccine manufacturers, animal health, and reproductive medicine, is now supporting approximately 45 clinical trials. The majority of these trials are regenerative therapies, including an array of CAR T-cell therapies. In total, these immunotherapy trials are expected to contribute as much as $150 million of revenue for Cryoport over the next five years.

The cryogenic logistics demands to support these therapies throughout their clinical trial phases increase over the life of the trial as data is collected and processed and the trial population size is expanded. Upon successful completion and approval by the U.S. Food and Drug Administration, these therapies are commercialized, providing a "hockey stick" shape to the demand curve for Cryoport's solutions.