Agenus Announces Collaboration and License Agreement with Merck for Novel Checkpoint Antibody-Based Cancer Immunotherapies

  • Agenus is eligible to receive ~$100 million in milestone payments as well as royalties on worldwide product sales

Agenus Inc. (AGEN) announced today that the company has entered into a collaboration and license agreement with Merck, known as MSD outside the United States and Canada, through a subsidiary, for the discovery and development of therapeutic antibodies to immune checkpoints for the treatment of cancer. Under the terms of the agreement, Agenus will discover and optimize fully human antibodies against two undisclosed Merck checkpoint targets using the 4-Antibody Retrocyte Display® platform. Merck will be responsible for clinical development and commercialization of candidates generated under the collaboration.

Read more: Agenus Inc ( AGEN )

Forest Laboratories to Acquire Furiex Pharmaceuticals for $1.1 Billion in Cash to Build on a Leading Position in Gastroenterology (GI)

Deal Also Includes Up to $30 per share in a Contingent Value Right for Furiex Shareholders

Creates a Leading GI Company within Forest
- Acquisition Adds Global Rights to Eluxadoline
- New Drug Application Expected to be Filed in 2014
- Eluxadoline is Complementary to Linzess for IBS-C and CIC and Additive to Forest’s GI Treatments Acquired in Acquisition of Aptalis

Forest to Partner with Royalty Pharma by Divesting Furiex’s Royalty Rights on Alogliptin and Priligy®

Read more: Furiex Pharmaceuticals Inc ( FURX )

Aastrom Announces Definitive Agreement to Acquire Sanofi's Cell Therapy and Regenerative Medicine Business

Acquisition of Landmark Autologous Cell Therapy Portfolio and Manufacturing Centers in U.S. and Europe Positions Aastrom as a Global Leader in Regenerative Medicine

Aastrom Biosciences, Inc. (ASTM), the leading developer of patient-specific, expanded multicellular therapies for the treatment of severe, chronic cardiovascular diseases, today announced that it has entered into a definitive agreement to acquire Sanofi's Cell Therapy and Regenerative Medicine (CTRM) business for a purchase price of $6.5 million, with $4 million payable in cash at closing and $2.5 million payable in the form of a promissory note. The acquisition is subject to customary closing conditions and is scheduled to close in approximately three weeks.

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Sarepta Therapeutics Announces Plans to Submit New Drug Application to FDA for Eteplirsen for the Treatment of Duchenne Muscular Dystrophy by Year End 2014

-- FDA provides updated guidance on potential early approval pathway for eteplirsen;
-- Agreement reached with the Agency on eteplirsen open-label confirmatory studies with enrollment of a broader base of DMD patients later this year;
-- FDA provides initial guidance on development of follow-on DMD drug candidates;
-- Company to hold teleconference at 8:00 a.m. EDT

Read more: Sarepta Therapeutics Inc ( SRPT )

Epirus and Zalicus Announce Merger Agreement

  • Merger will create a publicly traded, global biosimilar enterprise focused on improving patient access to important medicines

  • Epirus closes $36 million Series B financing round

  • Management to Hold Conference Call at 8:30 a.m. EDT

Epirus Biopharmaceuticals, Inc. (Epirus), a Boston-based biopharmaceutical company focused on the global development and commercialization of biosimilar monoclonal antibodies, and Zalicus Inc. (ZLCS) (Zalicus), announced today that they have entered into a definitive agreement under which Epirus will merge with a wholly-owned subsidiary of Zalicus in an all-stock transaction.

Read more: Zalicus Inc ( ZLCS )